Dexamethasone in veterinary clinical practice


Dexamethasone is an adrenal glucocorticosteroid with strong long-lasting effects, playing an anti-inflammatory and anti-allergic role, which has attracted the attention and concern of many doctors in recent years, especially the presence of a wide range of veterinary clinical treatment. The dosage of this drug is increasing, which will inevitably be accompanied by toxic side effects, and even cause the results of abuse, affecting the therapeutic effect of animal diseases and giving animals a certain amount of residual drugs, so how to properly use dexamethasone in veterinary clinics has become a more critical topic of medical progress.

Dexamethasone controls the accumulation of neutrophils at the site of inflammation, stabilizes the lysosomal membrane, reduces the vascular area, reduces vascular permeability, prevents the fusion or release of lysosomal and chemical inflammatory substances, regulates the cellular proliferation of connective tissue, and provides anti-inflammatory effects. This drug is used in the treatment of arthritis, ophthalmia, muscle or joint rheumatism to obtain acute effects. The anti-mycotic effect of dexamethasone can maintain the integrity of cell membranes, reduce the permeability of cell membranes themselves, prevent the entry of bacterial mesophiles into cells, and protect the body, so it is used in the treatment of sepsis, peritonitis, toxic pneumonia, or uterine infections to obtain the corresponding effect.

Dexamethasone effectively treats blood T-lymphocytes and monocytes, accelerates protein anisotropy, controls organic protein synthesis, hinders antibody synthesis, and has an anti-allergic effect. This drug is usually used in the treatment of light allergy, bronchial asthma or urticaria, however, it is difficult to show efficient therapeutic quality and alleviate the disease by using the drug singularly, so it is necessary to combine it with other types of drugs during clinical use to fully demonstrate the anti-allergic properties of dexamethasone drug. For anti-shock, it can stabilize the lysosomal membrane in the body, restrain the lysosomes from releasing changes, reduce the actual resistance of the external peripheral vessels, adjust the microcirculatory obstruction process, and promote the increase of the return blood volume, and the drug has a good effect on the treatment of toxic shock, traumatic shock, and cardiogenic shock.

Dexamethasone drug possesses the effect of intensifying hepatic gluconeogenic isogenesis and acts similarly to insulin, hindering the glucose oxidation process and reducing the utilization of sugar in the organism, so it is applied to pregnancy toxemia in horses and sheep. At the same time the drug promotes the secretion of large amounts of estrogen and reduces the actual concentration of luteinizing hormone, which contributes to the birthing operation in female animals. For the control of surgical sequelae, the drug can act on intestinal anastomosis as well as cesarean delivery to control the adhesions between the organism's organs and peritoneum and reduce the development of scarring of the wounds.